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Estrogen receptor - Androgens - Progesterone & steroids / SJW | Forum

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Agata Brown
Agata Brown Nov 14 '21
Mostly unsuccessful with trt as well as higher doses. I am better off on trt but in no way feels as if I am treating the route of the dysfunction - still cannot see any veins in my entire body/arms even with Cialis and nitric boosters. I’ve used Test before I tried SSRIs and it was extremely effective whereas now the results seem like they are unable to be tapped into due to the vascular/cardio dysfunction that comes with PSSD. I am thinking of trying nandrolone or trenbolone as an adjunct in order to upregulate both the androgen and estrogen receptor - these compounds do this through a sort of progestogenic mechanism that I’m going to delve into further. I’ve come across a few reports of low dose tren curing/reversing certain PSSD subtypes and given that I’ve been suffering for 3 years I’m willing to give it a go. I had a recent setback due to St johns Wort - the first 2-3 days were amazing - and then I was having non-stop reflux and migraines. It also seemed to affect my estrogen levels (subjectively) and after each testosterone injection, my anxiety levels would skyrocket. Apparently, it takes up to 2 weeks for SJW to completely clear the system so I am hoping to god I revert to pre SJW for the estrogenic disruption to clear. " St. John's wort (SJW) is a known strong inducer of the cytochrome P450 (CYP) 3 A4 enzyme, " I think this underlies its estrogenic/progestogenic interaction with my TRT.

Also - estrogen is said to normalize SERT expression resulting in reduced systemic 5HT and desensitized 1A - progesterone is thought to be an antagonist to estrogen 

Thoughts on adding Low dose tren roughly 100mg per week for 6 weeks to upregulate ERa/AR?
Max Velin
Max Velin Nov 14 '21
You know about all the risks and side effects, don't you? Please be careful with this. And consult a specialist about the dose. As I was quite cautious in my time in this regard. I got side effects in the form of poor potency. Now I have to remedy the situation with supertest 450 to get some relief.
Agata Brown
Agata Brown Nov 14 '21
It's a bit of a crybaby ending for you. What kind of steroids were you taking? I know about the side effects. But this is just too much.
bonder
bonder Jun 4
Legally you can buy steroids https://jbhnews.com/benefits-of-equipoise-side-effects-and-dosage/33232/ only if the use of steroids is legalized in your country. Otherwise it won’t be possible to use the steroid products lawfully. Also if in any case you face some serious health issue and no treatment is working that time the doctor’s prescription will help you to buy steroids maintaining the law.