ombining hydroxyzine and alcohol can have additive sedative effects on the central nervous system (CNS). Both substances can cause drowsiness, dizziness, and impaired coordination. When taken together, the sedative effects may be intensified, leading to increased risks of accidents, falls, and impaired judgment.

Additionally, hydroxyzine and alcohol can both cause dehydration, which can further contribute to potential health complications. Alcohol can also irritate the gastrointestinal system, potentially affecting the absorption and effectiveness of hydroxyzine.