I can't say either way man, I've never had to do this, but I'm sure I will experience it in the future.
Backup Database and Files and then try it out.
Trial and Error is the best way to learn sometimes...
With that being said, It's not recommended that anyone alter / modify the database unless you are a developer and know exactly what you're doing.
This is why I recommend everyone have a dev sub domain that you can test updates, experiment with idea's, develop plugins / themes / modifications.
It only takes like 5-10 minutes to setup a new install on a new sub domain, so why not?
Then you can load the dev setup with a current version (clone) of your production site and test the database removals without crashing your main site...
I might actually put this in my OxBackup / OxUpdater for the option to restore to new Database / Sub Domain.